SELECT PUBLICATIONS

Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS
He Tian (Tony) Chen* , Pratik Joshi*, Severine Cathelin , Soheil Jahangiri , Saeer A Adeel, Joshua Xu , Emily Tsao, Yulin Mo, David Kealy , Adam Dowle, Zaldy Balde, Marry Xuan , Dylan Gowlett-Park, Katarina Czibere, Alexandra Misura, Olga Bigun, Renato Sasso, August Lin, Noor Kundu, Dianne Chadwick, Sila Usta, Tina Khazaee, Signy Chow, Hubert Tsui, Mark D Minden, Andrew N Holding , Katherine S Bridge, Gang Zheng, Kristin J Hope. In press at Blood, 2026.

In vivo screening unveils pervasive RNA-binding protein dependencies in leukemic stem cells and identifies ELAVL1 as a therapeutic target
Vujovic A*, de Rooij L*, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. Blood Cancer Discovery. 2023 May 1;4(3):180-207. doi: 10.1158/2643-3230.BCD-22-0086

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal
Keyvani Chahi A, Belew MS, Xu J, Chen HTT, Rentas S, Voisin V, Krivdova G, Lechman E, Marhon SA, De Carvalho DD, Dick JE, Bader GD, Hope KJ. Blood. 2022 Sep 1;140(9):992-1008. doi: 10.1182/blood.2021014698

The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors
Liu L, Vujovic A, Deshpande NP, Sathe S, Anande G, Chen HTT, Xu J, Minden MD, Yeo GW, Unnikrishnan A, Hope KJ*, Lu Y*. Nature Communications. 2022 Jul 4;13(1):3833. doi: 10.1038/s41467-022-31155-0.

Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance.
Ly M, Rentas S, Vujovic A, Wong N, Moreira S, Xu J, Holzapfel N, Bhatia S, Tran D, Minden MD, Draper JS, Hope KJ. Cancer Research. 2019 Nov 15;79(22):5799-5811. doi: 10.1158/0008-5472.CAN-19-0274.

PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells
Belew MS, Bhatia S, Keyvani Chahi A, Rentas S, Draper JS, Hope KJ. Stem Cell Reports. 2018 Apr 10;10(4):1384-1397. doi: 10.1016/j.stemcr.2018.03.006.

Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.
Rentas S, Holzapfel N, Belew MS, Pratt G, Voisin V, Wilhelm BT, Bader GD, Yeo GW, Hope KJ. Nature. 2016 Apr 28;532(7600):508-511. doi: 10.1038/nature17665.

Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models.
Zhou X*, Moreira S*, Restelli C, Wang H, Jahangiri S, Aryal S, Tsao E, Zhang P, Niu M, Kumar H, Balde Z, Vujovic A, Liu L, Wong N, Arruda A, Minden MD, Zhou Y, Ravi B, Qi J, Li C, Hope KJ*, Lu R*. Science Translational Medicine. 2025 Aug 6;17(810):eadn5400. doi: 10.1126/scitranslmed.adn5400.

ALL PUBLICATIONS

  • Chen HT, Joshi P, Cathelin S, Jahangiri S, Adeel SA, Xu J, Tsao E, Mo Y, Kealy D, Dowle A, Balde Z, Xuan M, Gowlett-Park D, Czibere K, Misura A, Bigun O, Sasso R, Lin A, Kundu N, Chadwick D, Usta S, Khazaee T, Chow S, Tsui H, Minden MD, Holding AN, Bridge KS, Zheng G, Hope KJ. Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS. In press at Blood. 2026 doi: 10.1182/blood.2025030731

    Ling T, O'Brien C, St-Germain JR, Rondeau V, Shi M, Berman JM, Cepa A, Saez Raez P, Wunderlich M, Carter KM, Stillwell C, Sexton C, Culp-Hill R, Reisz JA, Adeel SA, Zeng AGX, Bansal S, Tsao E, Chen HT, Dick JE, Minden MD, Arruda A, Amaya ML, Tikhonova AN, Hope KJ, D'Alessandro A, Raught B, Jones CL. Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation. Blood. 2026 Feb 19;147(8):863-876. doi: 10.1182/blood.2025028933.

    O'Brien C, Nursimulu N, Tyagi A, Culp-Hill R, Arruda A, Murphy T, Minden MD, Kent A, Stevens B, Pollyea DA, Hope K, Kumar S, Reisz JA, D'Alessandro A, Jones CL. Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia. Blood. 2025 Nov 20;146(21):2589-2596. doi: 10.1182/blood.2025029132.

    Zhou X*, Moreira S*, Restelli C, Wang H, Jahangiri S, Aryal S, Tsao E, Zhang P, Niu M, Kumar H, Balde Z, Vujovic A, Liu L, Wong N, Arruda A, Minden MD, Zhou Y, Ravi B, Qi J, Li C, Hope KJ*, Lu R*. Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models. Sci Transl Med. 2025 Aug 6;17(810):eadn5400. doi: 10.1126/scitranslmed.adn5400.

  • Zhou X, Zhang L, Aryal S, Veasey V, Tajik A, Restelli C, Moreira S, Zhang P, Zhang Y, Hope KJ, Zhou Y, Cheng C, Bhatia R, Lu R. Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia. Blood. 2024 Nov 7;144(19):2018-2032. doi: 10.1182/blood.2023023644.

    Rondeau V, Berman JM, Ling T, O'Brien C, Culp-Hill R, Reisz JA, Wunderlich M, Chueh Y, Jiménez-Camacho KE, Sexton C, Carter KM, Stillwell C, St-Germain J, Yendi D, Gupta A, Shi M, Bourdine A, Paralkar VR, Jahangiri S, Hope KJ, Tikhonova AN, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL. Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models. Sci Transl Med. 2024 Sep 25;16(766):eadn1285. doi: 10.1126/scitranslmed.adn1285.

    Joshi P, Keyvani Chahi A, Liu L, Moreira S, Vujovic A, Hope KJ. RNA binding protein-directed control of leukemic stem cell evolution and function. Hemasphere. 2024 Aug 22;8(8):e116. doi: 10.1002/hem3.116.

    Vujovic A*, de Rooij L*, Chahi AK, Chen HT, Yee BA, Loganathan SK, Liu L, Chan DCH, Tajik A, Tsao E, Moreira S, Joshi P, Xu J, Wong N, Balde Z, Jahangiri S, Zandi S, Aigner S, Dick JE, Minden MD, Schramek D, Yeo GW, Hope KJ. In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target. Blood Cancer Discov. 2023 May 1;4(3):180-207. doi: 10.1158/2643-3230.BCD-22-0086.

    Kameda-Smith MM, Zhu H, Luo EC, Suk Y, Xella A, Yee B, Chokshi C, Xing S, Tan F, Fox RG, Adile AA, Bakhshinyan D, Brown K, Gwynne WD, Subapanditha M, Miletic P, Picard D, Burns I, Moffat J, Paruch K, Fleming A, Hope K, Provias JP, Remke M, Lu Y, Reya T, Venugopal C, Reimand J, Wechsler-Reya RJ, Yeo GW, Singh SK. Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nat Commun. 2022 Dec 6;13(1):7506. doi: 10.1038/s41467-022-35118-3. Erratum in: Nat Commun. 2023 Jan 10;14(1):136. doi: 10.1038/s41467-023-35816-6.

    Roma A, Tcheng M, Ahmed N, Walker S, Jayanth P, Minden MD, Hope K, Nekkar Rao PP, Luc J, Doxey AC, Reisz JA, Culp-Hill R, D'Alessandro A, Spagnuolo PA. Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia. Mol Cancer Res. 2022 Nov 3;20(11):1659-1673. doi: 10.1158/1541-7786.MCR-21-1032.

    Keyvani Chahi A, Belew MS, Xu J, Chen HTT, Rentas S, Voisin V, Krivdova G, Lechman E, Marhon SA, De Carvalho DD, Dick JE, Bader GD, Hope KJ. PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal. Blood. 2022 Sep 1;140(9):992-1008. doi: 10.1182/blood.2021014698.

    Liu L, Vujovic A, Deshpande NP, Sathe S, Anande G, Chen HTT, Xu J, Minden MD, Yeo GW, Unnikrishnan A, Hope KJ*, Lu Y*. The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors. Nat Commun. 2022 Jul 4;13(1):3833. doi: 10.1038/s41467-022-31155-0.

    Devoucoux M, Fort V, Khelifi G, Xu J, Alerasool N, Galloy M, Wong N, Bourriquen G, Fradet-Turcotte A, Taipale M, Hope K, Hussein SMI, Côté J. Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes. Cell Rep. 2022 Jun 14;39(11):110947. doi: 10.1016/j.celrep.2022.110947.

    Bakhshinyan D, Adile AA, Liu J, Gwynne WD, Suk Y, Custers S, Burns I, Singh M, McFarlane N, Subapanditha MK, Qazi MA, Vora P, Kameda-Smith MM, Savage N, Desmond KL, Tatari N, Tran D, Seyfrid M, Hope K, Bock NA, Venugopal C, Bader GD, Singh SK. Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence. Sci Adv. 2021 Dec 10;7(50):eabi5568. doi: 10.1126/sciadv.abi5568.

    Chan DCH, Xu J, Vujovic A, Wong N, Gordon V, de Rooij LPMH, Moreira S, Joyce CE, La Rose J, Sandí MJ, Doble BW, Novina CD, Rottapel RK, Hope KJ. Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis. Blood Adv. 2021 Aug 24;5(16):3120-3133. doi: 10.1182/bloodadvances.2020002539.

    Tcheng M, Roma A, Ahmed N, Smith RW, Jayanth P, Minden MD, Schimmer AD, Hess DA, Hope K, Rea KA, Akhtar TA, Bohrnsen E, D'Alessandro A, Mohsen AW, Vockley J, Spagnuolo PA. Very long chain fatty acid metabolism is required in acute myeloid leukemia. Blood. 2021 Jun 24;137(25):3518-3532. doi: 10.1182/blood.2020008551.

    Salim SK, Xu J, Wong N, Venugopal C, Hope KJ, Singh SK. Assessing the Safety of a Cell-Based Immunotherapy for Brain Cancers Using a Humanized Model of Hematopoiesis. STAR Protoc. 2020 Oct 7;1(3):100124. doi: 10.1016/j.xpro.2020.100124.

    Hope KJ. Making a bet on RET for hematopoietic stem cell expansion. Blood. 2020 Nov 26;136(22):2484-2486. doi: 10.1182/blood.2020007667.

    Keyvani Chahi A, Hope KJ. Hematopoiesis in High Definition: Combining State and Fate Mapping. Cell Stem Cell. 2020 Sep 3;27(3):354-355. doi: 10.1016/j.stem.2020.08.010.

    Vora P, Venugopal C, Salim SK, Tatari N, Bakhshinyan D, Singh M, Seyfrid M, Upreti D, Rentas S, Wong N, Williams R, Qazi MA, Chokshi C, Ding A, Subapanditha M, Savage N, Mahendram S, Ford E, Adile AA, McKenna D, McFarlane N, Huynh V, Wylie RG, Pan J, Bramson J, Hope K, Moffat J, Singh S. The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma. Cell Stem Cell. 2020 Jun 4;26(6):832-844.e6. doi: 10.1016/j.stem.2020.04.008.

  • Ly M, Rentas S, Vujovic A, Wong N, Moreira S, Xu J, Holzapfel N, Bhatia S, Tran D, Minden MD, Draper JS, Hope KJ. Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance. Cancer Res. 2019 Nov 15;79(22):5799-5811. doi: 10.1158/0008-5472.CAN-19-0274.

    de Rooij LPMH, Chan DCH, Keyvani Chahi A, Hope KJ. Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control 1. Biochem Cell Biol. 2019 Feb;97(1):10-20. doi: 10.1139/bcb-2017-0310.

    Belew MS, Bhatia S, Keyvani Chahi A, Rentas S, Draper JS, Hope KJ. PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2018 Apr 10;10(4):1384-1397. doi: 10.1016/j.stemcr.2018.03.006.

    Uddin M, Unda BK, Kwan V, Holzapfel NT, White SH, Chalil L, Woodbury-Smith M, Ho KS, Harward E, Murtaza N, Dave B, Pellecchia G, D'Abate L, Nalpathamkalam T, Lamoureux S, Wei J, Speevak M, Stavropoulos J, Hope KJ, Doble BW, Nielsen J, Wassman ER, Scherer SW, Singh KK. OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome. Am J Hum Genet. 2018 Feb 1;102(2):278-295. doi: 10.1016/j.ajhg.2018.01.006.

    Kwan V, Meka DP, White SH, Hung CL, Holzapfel NT, Walker S, Murtaza N, Unda BK, Schwanke B, Yuen RKC, Habing K, Milsom C, Hope KJ, Truant R, Scherer SW, Calderon de Anda F, Singh KK. DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Cell Rep. 2016 Nov 8;17(7):1892-1904. doi: 10.1016/j.celrep.2016.10.047.

    Ivetic N, Nazi I, Karim N, Clare R, Smith JW, Moore JC, Hope KJ, Kelton JG, Arnold DM. Producing megakaryocytes from a human peripheral blood source. Transfusion. 2016 May;56(5):1066-74. doi: 10.1111/trf.13461.

    Rentas S, Holzapfel N, Belew MS, Pratt G, Voisin V, Wilhelm BT, Bader GD, Yeo GW, Hope KJ. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells. Nature. 2016 Apr 28;532(7600):508-511. doi: 10.1038/nature17665.

  • Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault É, MacRae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G. RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. 2013 Aug 29;122(9):1545-55. doi: 10.1182/blood-2013-04-496281.

    Herault O, Hope KJ, Deneault E, Mayotte N, Chagraoui J, Wilhelm BT, Cellot S, Sauvageau M, Andrade-Navarro MA, Hébert J, Sauvageau G. A role for GPx3 in activity of normal and leukemia stem cells. J Exp Med. 2012 May 7;209(5):895-901. doi: 10.1084/jem.20102386.

    Hope KJ, Sauvageau G. Roles for MSI2 and PROX1 in hematopoietic stem cell activity. Curr Opin Hematol. 2011 Jul;18(4):203-7. doi: 10.1097/MOH.0b013e328347888a.

    Hope K, Bhatia M. Clonal interrogation of stem cells. Nat Methods. 2011 Apr;8(4 Suppl):S36-40. doi: 10.1038/nmeth.1590.

    Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell. 2010 Jul 2;7(1):101-13. doi: 10.1016/j.stem.2010.06.007.